The Roles of MicroRNA in Lung Cancer

Kuan-Li Wu; Ying-Ming Tsai; Chi-Tun Lien; Po-Lin Kuo; And Jen-Yu Hung

doi:10.3390/ijms20071611

The Roles of MicroRNA in Lung Cancer

Int J Mol Sci. 2019 Mar 31;20(7):1611. doi: 10.3390/ijms20071611.

Authors

Kuan-Li Wu^{1

2}, Ying-Ming Tsai^{3

4

5

6}, Chi-Tun Lien⁷, Po-Lin Kuo⁸, And Jen-Yu Hung^{9

10

11

12}

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
² Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
³ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
⁴ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
⁵ Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
⁶ Department of Respiratory Care, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
⁷ Department of Internal Medicine, Kaohsiung Municipal United Hospital, Kaohsiung 804, Taiwan. [email protected].
⁸ Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
⁹ Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
¹⁰ Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
¹¹ Department of Respiratory Care, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].
¹² Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. [email protected].

Abstract

Lung cancer is the most devastating malignancy in the world. Beyond genetic research, epigenomic studies-especially investigations of microRNAs-have grown rapidly in quantity and quality in the past decade. This has enriched our understanding about basic cancer biology and lit up the opportunities for potential therapeutic development. In this review, we summarize the involvement of microRNAs in lung cancer carcinogenesis and behavior, by illustrating the relationship to each cancer hallmark capability, and in addition, we briefly describe the clinical applications of microRNAs in lung cancer diagnosis and prognosis. Finally, we discuss the potential therapeutic use of microRNAs in lung cancer.

Keywords: lung cancer; microRNA.

Publication types

Review

MeSH terms

Animals
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism*
Gene Expression Regulation, Neoplastic / genetics
Humans
Lung Neoplasms / genetics*
Lung Neoplasms / metabolism*
Lung Neoplasms / pathology
MicroRNAs / genetics
MicroRNAs / metabolism*
Prognosis

Substances

Biomarkers, Tumor
MicroRNAs