Seasonal influenza vaccines induced high levels of neutralizing cross-reactive antibody responses against different genetic group influenza A(H1N1)pdm09 viruses

Anu Haveri; Niina Ikonen; Anu Kantele; Veli-Jukka Anttila; Eeva Ruotsalainen; Carita Savolainen-Kopra; Ilkka Julkunen

doi:10.1016/j.vaccine.2019.03.078

Seasonal influenza vaccines induced high levels of neutralizing cross-reactive antibody responses against different genetic group influenza A(H1N1)pdm09 viruses

Vaccine. 2019 May 6;37(20):2731-2740. doi: 10.1016/j.vaccine.2019.03.078. Epub 2019 Apr 4.

Authors

Anu Haveri¹, Niina Ikonen², Anu Kantele³, Veli-Jukka Anttila³, Eeva Ruotsalainen³, Carita Savolainen-Kopra², Ilkka Julkunen⁴

Affiliations

¹ Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare (THL), POB 30, 00271 Helsinki, Finland. Electronic address: [email protected].
² Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare (THL), POB 30, 00271 Helsinki, Finland.
³ Division of Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, POB 348, 00029 HUS Helsinki, Finland.
⁴ Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare (THL), POB 30, 00271 Helsinki, Finland; Institute of Biomedicine, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.

PMID: 30954308
DOI: 10.1016/j.vaccine.2019.03.078

Abstract

Influenza A(H1N1)pdm09 viruses have been circulating throughout the world since the 2009 pandemic. A/California/07/2009 (H1N1) virus was included in seasonal influenza vaccines for seven years altogether, providing a great opportunity to analyse vaccine-induced immunity in relation to the postpandemic evolution of the A(H1N1)pdm09 virus. Serum antibodies against various epidemic strains of influenza A(H1N1)pdm09 viruses were measured among health care workers (HCWs) by haemagglutination inhibition and microneutralization tests before and after 2010 and 2012 seasonal influenza vaccinations. We detected high responses of vaccine-induced neutralizing antibodies to six distinct genetic groups. Our results indicate antigenic similarity between vaccine and circulating A(H1N1)pdm09 strains, and substantial vaccine-induced immunity against circulating epidemic viruses.

Keywords: Antibodies; Humoral immunity; Influenza A; Microneutralization test; Pandemic; Vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / immunology*
Antibodies, Viral / immunology*
Hemagglutinin Glycoproteins, Influenza Virus / chemistry
Hemagglutinin Glycoproteins, Influenza Virus / immunology
Humans
Immunity, Humoral
Influenza A Virus, H1N1 Subtype / classification
Influenza A Virus, H1N1 Subtype / genetics*
Influenza A Virus, H1N1 Subtype / immunology*
Influenza Vaccines / immunology*
Influenza, Human / immunology*
Influenza, Human / prevention & control*
Neutralization Tests
Phylogeny
Seasons
Serologic Tests
Structure-Activity Relationship
Vaccination

Substances

Antibodies, Neutralizing
Antibodies, Viral
Hemagglutinin Glycoproteins, Influenza Virus
Influenza Vaccines