Phosphoinositides Break Microtubule Dynamics Symmetry in the Phragmoplast

Andrei Smertenko

doi:10.1016/j.tcb.2019.03.002

Phosphoinositides Break Microtubule Dynamics Symmetry in the Phragmoplast

Trends Cell Biol. 2019 Jun;29(6):449-451. doi: 10.1016/j.tcb.2019.03.002. Epub 2019 Apr 5.

Author

Andrei Smertenko¹

Affiliation

¹ Institute of Biological Chemistry, College of Human, Agricultural, and Natural Resource Sciences, Washington State University, Pullman, WA 99164, USA. Electronic address: [email protected].

PMID: 30962043
DOI: 10.1016/j.tcb.2019.03.002

Abstract

Glucocorticoids (GCs) are widely used for the management of disease- or therapy-related complications in cancer patients. Recent data indicate that activation of GC receptors (GRs) precipitates breast cancer progression by favoring metastatic dissemination and cell survival at distant sites. These findings call for the re-evaluation of GC usage in patients with cancer.

Keywords: ROR1; circulating tumor cells; dormancy; immunotherapy; social stress; triple negative breast cancer.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Microtubules / metabolism*
Phosphatidylinositols / metabolism*
Plants / metabolism*
Polymerization

Substances

Phosphatidylinositols