Computed tomography-guided percutaneous cryoablation for lung ground-glass opacity: A pilot study

J Cancer Res Ther. 2019;15(2):370-374. doi: 10.4103/jcrt.JCRT_299_18.

Abstract

Context: Ground-glass opacity (GGO) is a nonspecific imaging parameter for early-stage pulmonary cancer. In these cases, a definite diagnosis and prompt surgery usually yield satisfactory outcomes.

Aims: This study aimed to assess the safety and feasibility of cryoablation treatment for lung GGO.

Subjects and methods: We reviewed the clinical data of 14 patients (19 lung tumors) with lung GGO and evaluated the adverse events, lung function, and treatment efficacy after cryoablation.

Statistical analysis used: Statistical analyses were performed using the Statistical Package for the Social Sciences software (version 13.0; SPSS Inc., Chicago, IL, USA).

Results: None of the patients exhibited serious complications, and lung function recovered to >95% after 1 month. During a follow-up, computed tomography scan at 24 months, the GGO appeared to have been successfully ablated in all patients.

Conclusion: Cryoablation may serve as a safe and feasible option for the treatment of GGO.

Keywords: Ablation; cryoablation; ground-glass opacity.

MeSH terms

  • Aged
  • Biomarkers
  • Cryosurgery* / methods
  • Female
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / therapy*
  • Male
  • Middle Aged
  • Pilot Projects
  • Respiratory Function Tests
  • Retrospective Studies
  • Surgery, Computer-Assisted*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Biomarkers