Assessment of Monocyte/HDL Ratio in Branch Retinal Vein Occlusion

Ocul Immunol Inflamm. 2020 Apr 2;28(3):463-467. doi: 10.1080/09273948.2019.1569244. Epub 2019 Apr 9.

Abstract

Purpose: The purpose of this article was to evaluate monocyte count and high-density lipoprotein (HDL) cholesterol levels and their ratio (monocyte/HDL ratio [MHR]) in patients with branch retinal vein occlusion (BRVO).Materials and Methods: A total of 50 participants were included in the study. Participants were divided into two groups: Twenty-five patients diagnosed with BRVO and 25 participants as the control group. Ocular examination findings and hematologic parameters were accessed from the file records and database, retrospectively.Results: The mean MHR was significantly higher in BRVO group compared to the control group (13.4 ± 5.2 vs. 8.1 ± 2.2, p < 0.001). In receiver operating characteristics analysis, the area under the curve for MHR was 0.862, and an MHR of >9.5 predicted BRVO with a sensitivity of 76% and specificity of 70.8%.Conclusion: The present study showed that elevated MHR is significantly associated with BRVO. Therefore, MHR may be a useful marker for the emergence of BRVO.

Keywords: BRVO; Branch retinal vein occlusion; MHR; Monocyte/high-density lipoprotein cholesterol (HDL) ratio; inflammation.

MeSH terms

  • Aged
  • Biomarkers / blood*
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Leukocyte Count
  • Lipoproteins, HDL / blood*
  • Male
  • Monocytes / metabolism*
  • Prognosis
  • Retinal Vein Occlusion / blood*
  • Retinal Vein Occlusion / diagnosis
  • Retinal Vessels / diagnostic imaging*
  • Retrospective Studies
  • Severity of Illness Index
  • Slit Lamp Microscopy
  • Tomography, Optical Coherence
  • Visual Acuity*

Substances

  • Biomarkers
  • Lipoproteins, HDL