Microwave-assisted green synthesis of anilines, phenols, and benzenediamines without transition metals, ligands, or organic solvents

Green Chem Lett Rev. 2018;11(3):286-295. doi: 10.1080/17518253.2018.1486464. Epub 2018 Jul 3.

Abstract

A novel, microwave-assisted method producing anilines and phenols from activated aryl halides is reported. This high-yielding method reduces current reaction requirements and removes organic solvents and catalysts making a more efficient and eco-friendly alternative for the synthesis of important pharmaceutical building blocks.

Keywords: Amination; aminophenol; benzenediamine; hydroxylation; reduction.