Taichunins A-D, Norditerpenes from Aspergillus taichungensis (IBT 19404)

J Nat Prod. 2019 May 24;82(5):1377-1381. doi: 10.1021/acs.jnatprod.8b01032. Epub 2019 Apr 17.

Abstract

Four new norditerpenes, taichunins A-D (1-4), were isolated from the fungus Aspergillus taichungensis (IBT 19404). Compound 1 has a new carbon framework. The absolute configurations were determined by the calculated ECD spectral method. Compound 1 was cytotoxic against HeLa cells with an IC50 value of 4.5 μM, whereas 2-4 were nontoxic at 50 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology*
  • Anticholesteremic Agents / pharmacology
  • Aspergillus / chemistry*
  • Diterpenes / chemistry
  • Diterpenes / pharmacology*
  • HeLa Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Osteoclasts / drug effects
  • Proteasome Endopeptidase Complex / drug effects
  • RANK Ligand / drug effects
  • RANK Ligand / metabolism

Substances

  • Anti-Infective Agents
  • Antibiotics, Antineoplastic
  • Anticholesteremic Agents
  • Diterpenes
  • RANK Ligand
  • TNFSF11 protein, human
  • Proteasome Endopeptidase Complex