Sister, Sister: Ependymal Cells and Adult Neural Stem Cells Are Separated at Birth by Geminin Family Members

Ryann M Fame; Maria K Lehtinen

doi:10.1016/j.neuron.2019.02.040

Sister, Sister: Ependymal Cells and Adult Neural Stem Cells Are Separated at Birth by Geminin Family Members

Neuron. 2019 Apr 17;102(2):278-279. doi: 10.1016/j.neuron.2019.02.040.

Authors

Ryann M Fame¹, Maria K Lehtinen²

Affiliations

¹ Department of Pathology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
² Department of Pathology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: [email protected].

PMID: 30998898
DOI: 10.1016/j.neuron.2019.02.040

Abstract

The adult subventricular zone (SVZ) stem cell niche is comprised of multi-ciliated ependymal cells that line the brain ventricular system and adult stem cells. Papers in Neuron (Ortiz-Álvarez et al., 2019) and Cell Reports (Redmond et al., 2019) report that these cell types share a common precursor. Ortiz-Álvarez et al. further show that Geminin family members modulate the fate of daughter cells.

Publication types

Comment

MeSH terms

Adult
Adult Stem Cells*
Ependyma
Geminin
Humans
Infant, Newborn
Lateral Ventricles
Neural Stem Cells*

Substances

Geminin