Abstract
Ubiquitin-like/ubiquitin-associated proteins (UbL-UbA) are a well-studied family of non-proteasomal ubiquitin receptors that are evolutionarily conserved across species. Members of this non-homogenous family facilitate and support proteasomal activity by promoting different effects on proteostasis but exhibit diverse extra-proteasomal activities. Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In this review, we summarized the properties and functions of UbL-UbA family members identified to date, with an emphasis on new findings obtained using Drosophila models showing a direct or indirect role in some neurodegenerative diseases.
Keywords:
Drosophila; UbL-UbA; neurodegenerative diseases; non-proteasomal ubiquitin receptor; proteostasis; ubiquitin-like.
MeSH terms
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Adaptor Proteins, Signal Transducing
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Animals
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Autophagy-Related Proteins
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Carrier Proteins / metabolism
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Cell Cycle Proteins / metabolism
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DNA Repair Enzymes / metabolism
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DNA-Binding Proteins / metabolism
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Disease Models, Animal
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Drosophila
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism
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Neurodegenerative Diseases / metabolism*
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Neurodegenerative Diseases / pathology
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Neurons / metabolism
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Neurons / pathology*
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Proteasome Endopeptidase Complex / metabolism
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Proteostasis
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Transcription Factors / metabolism
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Ubiquitin / metabolism*
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Ubiquitin-Protein Ligases
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Ubiquitins / metabolism*
Substances
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Adaptor Proteins, Signal Transducing
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Autophagy-Related Proteins
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Carrier Proteins
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Cell Cycle Proteins
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DNA-Binding Proteins
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Intracellular Signaling Peptides and Proteins
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NUB1 protein, human
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Transcription Factors
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UBQLN1 protein, human
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Ubiquitin
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Ubiquitins
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RAD23A protein, human
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UBAC1 protein, human
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Ubiquitin-Protein Ligases
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Proteasome Endopeptidase Complex
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DNA Repair Enzymes