"Cloaking" on Time: A Cover-Up Act by Resident Tissue Macrophages

Camille Blériot; Lai Guan Ng; Florent Ginhoux

doi:10.1016/j.cell.2019.03.042

"Cloaking" on Time: A Cover-Up Act by Resident Tissue Macrophages

Cell. 2019 Apr 18;177(3):514-516. doi: 10.1016/j.cell.2019.03.042.

Authors

Camille Blériot¹, Lai Guan Ng², Florent Ginhoux³

Affiliations

¹ Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), 8A Biomedical Grove, Immunos Building #3-4, Biopolis, Singapore 138648, Singapore.
² Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), 8A Biomedical Grove, Immunos Building #3-4, Biopolis, Singapore 138648, Singapore; State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, 288 Nanjing Road, Tianjin 300020, China.
³ Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), 8A Biomedical Grove, Immunos Building #3-4, Biopolis, Singapore 138648, Singapore; Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address: [email protected].

PMID: 31002790
DOI: 10.1016/j.cell.2019.03.042

Abstract

In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue damage.

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MeSH terms

Macrophages*
Neutrophils*