Benzylarylation of N-Allyl Anilines: Synthesis of Benzylated Indolines

J Org Chem. 2019 May 17;84(10):6072-6083. doi: 10.1021/acs.joc.9b00237. Epub 2019 May 6.

Abstract

An unprecedented benzylic C-H functionalization of methyl arenes across unactivated alkenes is presented. In the presence of MnCl2·4H2O and di- tert-butyl peroxide, N-allyl anilines underwent benzylation/cyclization cascade to give benzylated indolines, which are a previously unmet synthetic goal. This protocol features simple operation, broad substrate scope, and great exo selectivity.

Publication types

  • Research Support, Non-U.S. Gov't