Abstract
We report the first therapeutic infusion of haploidentical virus-specific T lymphocytes (VSTs) to treat maternally-transmitted, disseminated adenovirus infection in a premature infant. Infusion of maternal VSTs, isolated using interferon-gamma capture, associated with clinical improvement and viral clearance.
Publication types
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Case Reports
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenoviridae Infections* / immunology
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Adenoviridae Infections* / pathology
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Adenoviridae Infections* / therapy
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Adoptive Transfer*
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Female
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Humans
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Infant, Newborn
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Infant, Newborn, Diseases* / immunology
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Infant, Newborn, Diseases* / pathology
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Infant, Newborn, Diseases* / therapy
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Infant, Premature
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T-Lymphocytes* / immunology
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T-Lymphocytes* / transplantation