An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas

Mod Pathol. 2019 Oct;32(10):1390-1415. doi: 10.1038/s41379-019-0280-2. Epub 2019 Apr 25.

Abstract

Our understanding of serrated colorectal polyps has increased dramatically over the past two decades and has led to a modern classification scheme for these lesions. Sessile serrated polyps with dysplasia represent the most clinically significant serrated polyp; however, the morphologic heterogeneity of dysplasia in sessile serrated polyps has only recently been recognized and correlated with MLH1 immunohistochemistry. Detailed morphologic analysis of traditional serrated adenomas has led to the recognition of flat and early forms of this polyp. Robust data on the risk of metachronous lesions in patients with serrated polyps are also beginning to emerge. This review will summarize our current understanding of serrated polyps and associated carcinomas with a focus on diagnostic criteria, morphologic heterogeneity, molecular findings, and natural history. Controversial issues in the diagnosis and classification of these polyps are also discussed.

Publication types

  • Review

MeSH terms

  • Adenoma / metabolism
  • Adenoma / pathology*
  • Colonic Polyps / metabolism
  • Colonic Polyps / pathology*
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology*
  • Humans
  • Immunohistochemistry
  • MutL Protein Homolog 1 / metabolism
  • Pathology, Molecular

Substances

  • MutL Protein Homolog 1