Persisting enteropathy and disturbed adaptive mucosal immunity due to MHC class II deficiency

Clin Immunol. 2019 Jun:203:125-133. doi: 10.1016/j.clim.2019.04.012. Epub 2019 Apr 24.

Abstract

Intestinal epithelial cells (IECs) form a fundamental mucosal barrier and actively participate in tolerance and immunity against intestinal contents. Major histocompatibility complex class II (MHC II) and invariant chain (Ii) molecules are essential for adaptive immune response. MHC II deficiency often presents with gastrointestinal disorders. Intestinal biopsy samples revealed an absence of HLA-DR, Ii, and local immunoglobulins in both hematopoietic immune cells and IECs accompanied by a lack of faecal sIgA. After successful hematopoietic stem cell transplantation (HSCT) absent HLA-DR and Ii expression persisted in IECs and faecal stool analysis indicated inflammation and high microbial activity. We describe multifaceted disturbance of adaptive mucosal immunity in MHC II deficient patients suffering from enteropathy. HLA-DR and Ii expression on enterocytes is not restored by HSCT. This may account for increased susceptibility to enteric infections and intestinal inflammation leading to prolonged enteropathy reported in MHC II deficient patients.

Keywords: Adaptive immunity; Enteropathy; HLA-DR; Hematopoietic stem cell transplantation; Intestinal epithelial cells; Invariant chain; MHC class II deficiency; Mucosal immunity.

MeSH terms

  • Adaptive Immunity
  • Adolescent
  • Child
  • Child, Preschool
  • DNA Mutational Analysis
  • DNA-Binding Proteins / genetics
  • Female
  • Gastrointestinal Diseases / genetics
  • Gastrointestinal Diseases / immunology*
  • HLA-DR Antigens / genetics*
  • HLA-DR Antigens / metabolism
  • Humans
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / immunology*
  • Infant
  • Inflammation / genetics
  • Inflammation / immunology*
  • Intestinal Mucosa / immunology*
  • Male
  • Mutation / genetics
  • Pedigree
  • Transcription Factors / genetics

Substances

  • DNA-Binding Proteins
  • HLA-DR Antigens
  • RFXANK protein, human
  • RFXAP protein, human
  • Transcription Factors