Non-drug and drug alternatives to benzodiazepines for insomnia in primary care: Study among GPs and pharmacies in a Southwest region of France

Therapie. 2019 Oct;74(5):537-546. doi: 10.1016/j.therap.2019.03.004. Epub 2019 Apr 2.

Abstract

Objectives: Benzodiazepines and related drugs are the most commonly prescribed drugs in the treatment of insomnia, and referral to psychotherapy is rare when recommended as first-line treatment for chronic insomnia. The frequency of referral to psychologists, of use of alternative drugs to benzodiazepines, either prescribed by general practitioners (GPs) or dispensed by community pharmacies, is unknown in France. We aimed to describe the non-pharmacological approaches recommended, such as cognitive behavioral therapies (CBT), and the drugs, including alternatives drugs to benzodiazepines, used by GPs and community pharmacies for patients complaining of insomnia.

Methods: A cross-sectional study was conducted during 3 months in 2015 on the management of individual GPs' patients and pharmacies' customers consecutively consulting for insomnia in the Midi-Pyrénées region of southwest France. Participating GPs and pharmacists completed a form, for each patient, on their management (drugs, sleeping advices, referral to psychotherapy).

Results: Fifty-five GPs included 263 patients and 43 community pharmacies included 354 customers in the study. Among patients, 193 (73,4%) had already used benzodiazepine. Thirty-eight patients (14.4%) and 2 customers (0.5%) were recommended non-drug therapies (mostly CBT). Benzodiazepines were prescribed 188 times (69.1% of the prescriptions) by GPs. Alternative drugs prescribed were mostly antihistamines (n=26; 9.6%) and antidepressants (n=17; 6.3%). Antihistamines were the most commonly dispensed drugs by pharmacists (n=149; 39.4%).

Conclusions: While non-pharmacological treatments, such as CBT, are safe and widely recommended, benzodiazepines and antihistamines remain widely used despite the lack of long term benefit and the risk of adverse drug reactions.

Keywords: Community pharmacy services; General practitioners; Hypnotics and sedatives; Patient care management; Psychotherapy; Sleep initiation and maintenance disorders.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Antidepressive Agents / therapeutic use
  • Benzodiazepines / therapeutic use*
  • Cognitive Behavioral Therapy* / statistics & numerical data
  • Cross-Sectional Studies
  • Female
  • France
  • General Practice / statistics & numerical data
  • General Practitioners / statistics & numerical data*
  • Histamine Antagonists / therapeutic use
  • Humans
  • Hypnotics and Sedatives / therapeutic use
  • Male
  • Meditation
  • Middle Aged
  • Pharmacies / statistics & numerical data
  • Pharmacists / statistics & numerical data*
  • Primary Health Care
  • Referral and Consultation
  • Relaxation
  • Sleep Initiation and Maintenance Disorders / therapy*

Substances

  • Antidepressive Agents
  • Histamine Antagonists
  • Hypnotics and Sedatives
  • Benzodiazepines