A lymphoma patient with Cytomegalovirus retinitis and post-autologous hematopoietic cell transplantation immune reconstitution uveitis: A case report and review of the literature

Transpl Infect Dis. 2019 Aug;21(4):e13099. doi: 10.1111/tid.13099. Epub 2019 May 11.

Abstract

Cytomegalovirus (CMV) retinitis in hematologic malignancies in the absence of hematopoietic cell transplant (HCT) is uncommon. We report a case of a 54-year-old woman with peripheral T-cell lymphoma who develops CMV retinitis and subsequently undergoes an autologous HCT, with eventual development of immune reconstitution uveitis. We further reviewed the PubMed literature on CMV retinitis in patients with lymphoma. We describe that CMV retinitis in patients with lymphoma has variable clinical presentations, may occur at any time during the course of the disease and chemotherapy, and is associated with significant morbidity.

Keywords: Cytomegalovirus; hematopoietic cell transplantation; immune reconstitution uveitis; lymphoma; retinitis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Cytomegalovirus / immunology
  • Cytomegalovirus Retinitis / diagnosis*
  • Cytomegalovirus Retinitis / immunology
  • Female
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immune Reconstitution Inflammatory Syndrome / etiology*
  • Lymphoma / complications
  • Lymphoma / virology*
  • Middle Aged
  • Uveitis / etiology*