4-Coumarate 3-hydroxylase in the lignin biosynthesis pathway is a cytosolic ascorbate peroxidase

Nat Commun. 2019 Apr 30;10(1):1994. doi: 10.1038/s41467-019-10082-7.

Abstract

Lignin biosynthesis is evolutionarily conserved among higher plants and features a critical 3-hydroxylation reaction involving phenolic esters. However, increasing evidence questions the involvement of a single pathway to lignin formation in vascular plants. Here we describe an enzyme catalyzing the direct 3-hydroxylation of 4-coumarate to caffeate in lignin biosynthesis as a bifunctional peroxidase that oxidizes both ascorbate and 4-coumarate at comparable rates. A combination of biochemical and genetic evidence in the model plants Brachypodium distachyon and Arabidopsis thaliana supports a role for this coumarate 3-hydroxylase (C3H) in the early steps of lignin biosynthesis. The subsequent efficient O-methylation of caffeate to ferulate in grasses is substantiated by in vivo biochemical assays. Our results identify C3H as the only non-membrane bound hydroxylase in the lignin pathway and revise the currently accepted models of lignin biosynthesis, suggesting new gene targets to improve forage and bioenergy crops.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arabidopsis / metabolism
  • Ascorbate Peroxidases
  • Brachypodium / metabolism
  • Caffeic Acids / metabolism
  • Coumaric Acids / metabolism
  • Cytosol / enzymology*
  • Lignin / biosynthesis*
  • Mixed Function Oxygenases / genetics
  • Mixed Function Oxygenases / metabolism
  • Plant Proteins / genetics
  • Plant Proteins / metabolism

Substances

  • Caffeic Acids
  • Coumaric Acids
  • Plant Proteins
  • Lignin
  • Mixed Function Oxygenases
  • Ascorbate Peroxidases
  • caffeic acid