Rapid detection of invasive Mycobacterium chimaera disease via a novel plasma-based next-generation sequencing test

BMC Infect Dis. 2019 May 2;19(1):371. doi: 10.1186/s12879-019-4001-8.

Abstract

Background: There is an ongoing outbreak of Mycobacterium chimaera infections among patients exposed to contaminated heater-cooler devices used during cardiac surgery. Recognition of M. chimaera infection is hampered by its long latency and non-specific symptoms. Standard diagnostic methods using acid-fast bacilli (AFB) culture often require invasive sampling, have low sensitivity, and can take weeks to result. We describe the performance of a plasma-based next-generation sequencing test (plasma NGS) for the diagnosis of M. chimaera infection.

Methods: We conducted a retrospective study of 10 patients with a history of cardiac surgery who developed invasive M. chimaera infection and underwent testing by plasma NGS between February 2017 and April 2018.

Results: Plasma NGS detected M. chimaera in 9 of 10 patients (90%) with invasive disease in a median of 4 days from specimen collection, including all 8 patients with disseminated infection. In 7 of these 9 cases (78%), plasma NGS was the first test to provide microbiologic confirmation of M. chimaera infection. In contrast, AFB cultures required a median of 20 days to turn positive, and the median time for confirmation of M. chimaera was 41 days. Of 24 AFB blood cultures obtained in this cohort, only 4 (17%) were positive. Invasive procedures were performed in 90% of cases, and in 5 patients (50%), mycobacterial growth was achieved only by culture of these deep sites.

Conclusions: Plasma NGS can accurately detect M. chimaera noninvasively and significantly faster than AFB culture, making it a promising new diagnostic tool.

Keywords: Cell-free DNA; Heater-cooler devices; Mycobacterium chimaera infection; Next-generation sequencing.

MeSH terms

  • Aged
  • DNA, Bacterial / blood
  • DNA, Bacterial / metabolism
  • Disease Outbreaks
  • Female
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Male
  • Middle Aged
  • Mycobacterium / genetics*
  • Mycobacterium / isolation & purification
  • Mycobacterium Infections / diagnosis*
  • Mycobacterium Infections / microbiology
  • Retrospective Studies
  • Sequence Analysis, DNA

Substances

  • DNA, Bacterial