Abstract
The qacA/B gene is one of the major determinants of resistance to antiseptics in methicillin-resistant Staphylococcus aureus (MRSA). Here, we compared the fast-acting bactericidal activity of skin antiseptics, including olanexidine gluconate (OLG), a new biguanide antiseptic agent introduced in Japan, against clinical qacA/B-positive MRSA strains by determination of minimum bactericidal concentration and time-kill assay. Our findings provide, for the first time, data indicating that the fast-acting bactericidal activity of OLG against qacA/B-positive MRSA is higher than that of chlorhexidine gluconate, even though both are biguanide antiseptics.
Keywords:
fast-acting bactericidal activity; olanexidine; qacA/B-positive methicillin-resistant Staphylococcus aureus.
MeSH terms
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Anti-Infective Agents, Local / pharmacology*
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Bacterial Proteins / genetics*
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Biguanides / pharmacology*
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Chlorhexidine / analogs & derivatives
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Chlorhexidine / pharmacology
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Glucuronates / pharmacology*
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Membrane Transport Proteins / genetics*
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Methicillin / pharmacology
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / enzymology
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Methicillin-Resistant Staphylococcus aureus / genetics
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / microbiology*
Substances
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Anti-Infective Agents, Local
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Bacterial Proteins
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Biguanides
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Glucuronates
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Membrane Transport Proteins
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QacB protein, Staphylococcus aureus
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qacA protein, Staphylococcus aureus
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olanexidine gluconate
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chlorhexidine gluconate
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Methicillin
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Chlorhexidine