The current state of randomized clinical trial evidence for prostate brachytherapy

Robert T Dess; Payal D Soni; William C Jackson; Alejandro Berlin; Brett W Cox; Shruti Jolly; Jason A Efstathiou; Felix Y Feng; Amar U Kishan; Bradley J Stish; Thomas M Pisansky; Daniel E Spratt

doi:10.1016/j.urolonc.2019.04.009

The current state of randomized clinical trial evidence for prostate brachytherapy

Urol Oncol. 2019 Sep;37(9):599-610. doi: 10.1016/j.urolonc.2019.04.009. Epub 2019 May 3.

Authors

Affiliations

¹ Department of Radiation Oncology, University of Michigan, Ann Arbor, MI. Electronic address: [email protected].
² Department of Radiation Oncology, Hunter Holmes McGuire VA Medical Center, Richmond, VA.
³ Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
⁴ Department of Radiation Oncology, University of Toronto, Toronto, Canada.
⁵ Department of Radiation Medicine, Northwell Health, Hofstra Northwell School of Medicine, Hempstead, NY.
⁶ Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA.
⁷ Departments of Radiation Oncology, Urology and Medicine, University of California San Francisco, San Francisco, CA.
⁸ Department of Radiation Oncology, University of California Los Angeles, Los Angeles, CA.
⁹ Department of Radiation Oncology, Mayo Clinic, Rochester, MN.

PMID: 31060795
DOI: 10.1016/j.urolonc.2019.04.009

Abstract

Interstitial brachytherapy is one of several curative therapeutic options for the treatment of localized prostate cancer. In this review, we summarize all available randomized data to support the optimal use of prostate brachytherapy. Evidence from completed randomized controlled trials is the focus of this review with a presentation also of important ongoing trials. Gaps in knowledge are identified where future investigation may be fruitful with intent to inspire well-designed prospective studies with standardized treatment that focuses on improving oncological outcomes, reducing morbidity, or maintaining quality of life.

Keywords: Brachytherapy; Combination therapy; HDR; LDR; Prostate cancer.

Publication types

Review

MeSH terms

Brachytherapy / methods*
Humans
Male
Prostatic Neoplasms / radiotherapy*
Radiotherapy Dosage
Randomized Controlled Trials as Topic