SIRT1 Regulates Lysosome Function and Exosome Secretion

Kathleen M McAndrews; Valerie S LeBleu; Raghu Kalluri

doi:10.1016/j.devcel.2019.04.024

SIRT1 Regulates Lysosome Function and Exosome Secretion

Dev Cell. 2019 May 6;49(3):302-303. doi: 10.1016/j.devcel.2019.04.024.

Authors

Kathleen M McAndrews¹, Valerie S LeBleu², Raghu Kalluri³

Affiliations

¹ Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.
² Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
³ Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA. Electronic address: [email protected].

PMID: 31063745
DOI: 10.1016/j.devcel.2019.04.024

Abstract

The NAD⁺-dependent deacetylase Sirtuin 1 (SIRT1) regulates cell metabolism, proliferation, and DNA repair and acts as a tumor suppressor in breast cancer. In this issue of Developmental Cell, Latifkar et al. show that SIRT1 controls lysosomal acidification and its loss enhances the secretion of pro-tumorigenic exosomes for breast cancer invasion.

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MeSH terms

Breast Neoplasms*
Carcinogenesis
Exosomes*
Humans
Lysosomes
Sirtuin 1

Substances

SIRT1 protein, human
Sirtuin 1