The present study assessed the correlations between cerebral regional saturation detected by near infrared spectroscopy (NIRS) and cardiac index (CI) measured by pulmonary artery catheter. This was a retrospective cohort study conducted in the cardiac intensive care unit in a tertiary care children's hospital. Patients younger than 18 years of age who underwent heart transplantation and had a pulmonary artery catheter on admission to the pediatric cardiac intensive care unit between January, 2010, and August, 2013, were included. There were no interventions. A total of 10 patients were included with median age of 14 years (range, 7-17). Indications for transplantation were dilated cardiomyopathy ( n = 9) and restrictive cardiomyopathy ( n = 1). Mixed venous oxygen saturation (SvO 2 ), cerebral regional tissue saturation (rSO 2 ), and CI were recorded hourly for 8 to 92 hours post-transplantation. Spearman's rank correlation coefficient was used to assess correlations between SvO 2 and cerebral rSO 2 and between CI and cerebral rSO 2 . A total of 410 data points were collected. Median, 25th and 75th percentiles of cerebral rSO 2 , CI, and SvO 2 were 65% (54-69), 2.9 L/min/m 2 (2.2-4.0), and 75% (69-79), respectively. The correlation coefficient between cerebral rSO 2 and CI was 0.104 ( p = 0.034) and that for cerebral rSO 2 and SvO 2 was 0.11 ( p = 0.029). The correlations between cerebral rSO 2 and CI and between cerebral rSO 2 and SvO 2 were weak. Cerebral rSO 2 as detected by NIRS may not be an accurate indicator of CI in critically ill patients.
Keywords: cardiac index; cardiac output; cerebral near infrared spectroscopy; heart transplant; mixed venous saturation; pediatric; regional oxygen saturation.