Corynebacterium diphtheriae- infective endocarditis in a patient with an atrial septal defect closure device

BMJ Case Rep. 2019 May 9;12(5):e229478. doi: 10.1136/bcr-2019-229478.

Abstract

An 18-year-old woman presented to our institution with fever, bilateral flank pain, headache and photophobia. She had a previous atrial septal defect (ASD) closure device inserted at the age of 9 years. Blood cultures on admission were positive for Corynebacterium diphtheriae, and transoesophageal echocardiogram (TOE) revealed an echodensity associated with the ASD closure device, most consistent with a vegetation. She was treated for infective endocarditis with 6 weeks of intravenous benzylpenicillin, and follow-up TOE showed resolution of the echodensity. To our knowledge, no cases of C. diphtheriaeendocarditis of an ASD closure device have previously been reported.

Keywords: cardiovascular medicine; clinical diagnostic tests; infections; infectious diseases.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / administration & dosage*
  • Corynebacterium diphtheriae / isolation & purification*
  • Echocardiography, Transesophageal
  • Endocarditis / diagnosis*
  • Endocarditis / drug therapy
  • Endocarditis / physiopathology
  • Female
  • Fever / microbiology
  • Flank Pain / microbiology
  • Heart Septal Defects, Atrial / surgery*
  • Humans
  • Infusions, Intravenous
  • Penicillin G / administration & dosage*
  • Photophobia / microbiology
  • Prosthesis-Related Infections / drug therapy
  • Prosthesis-Related Infections / microbiology*
  • Septal Occluder Device / adverse effects
  • Septal Occluder Device / microbiology*
  • Time Factors
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Penicillin G