Fatal Yellow Fever in a Kidney Transplant Patient

Lígia C Pierrotti; Amaro N Duarte-Neto; Alice T W Song; Carlucci G Ventura; Elias David-Neto; Luiz S Azevedo

doi:10.1093/cid/ciz389

Fatal Yellow Fever in a Kidney Transplant Patient

Clin Infect Dis. 2020 Jan 1;70(1):144-148. doi: 10.1093/cid/ciz389.

Authors

Lígia C Pierrotti^{1

2}, Amaro N Duarte-Neto³, Alice T W Song⁴, Carlucci G Ventura⁵, Elias David-Neto⁵, Luiz S Azevedo⁵

Affiliations

¹ Infectious Diseases Division, Hospital das Clinicas, Universidade de São Paulo, Brazil.
² Center for Clinical Research, Diagnósticos da América Laboratory, Brazil.
³ Pathology Department, Hospital das Clinicas, Universidade de São Paulo, Brazil.
⁴ LIM-37, Liver Transplantation Laboratory, Universidade de São Paulo, Brazil.
⁵ Renal Transplantation Service, Hospital das Clinicas, Universidade de São Paulo, Brazil.

PMID: 31077273
DOI: 10.1093/cid/ciz389

Abstract

A kidney-transplanted patient, unvaccinated against yellow fever (YF), developed high fever, progressed rapidly to hepatic insufficiency and coma, and died 8 days later. Real-time polymarase chain reaction for YF virus collected on the seventh day of symptoms was positive. Autopsy showed disseminated infection and midzonal hepatitis with apoptotic hepatocytes and minimal inflammatory reaction.

Keywords: kidney transplantation; organ transplantation; yellow fever; yellow fever vaccine.

MeSH terms

Humans
Kidney Transplantation* / adverse effects
Yellow Fever Vaccine*
Yellow Fever* / diagnosis
Yellow fever virus / genetics

Substances

Yellow Fever Vaccine