Spread of ESBL-producing Escherichia coli in nursing home residents in Ireland and the Netherlands may reflect infrastructural differences

E M Terveer; M Fallon; M E M Kraakman; A Ormond; M Fitzpatrick; M A A Caljouw; A Martin; S M van Dorp; M C Wong; E J Kuijper; F Fitzpatrick

doi:10.1016/j.jhin.2019.05.003

Spread of ESBL-producing Escherichia coli in nursing home residents in Ireland and the Netherlands may reflect infrastructural differences

J Hosp Infect. 2019 Oct;103(2):160-164. doi: 10.1016/j.jhin.2019.05.003. Epub 2019 May 9.

Authors

E M Terveer¹, M Fallon², M E M Kraakman³, A Ormond⁴, M Fitzpatrick⁴, M A A Caljouw⁵, A Martin⁶, S M van Dorp³, M C Wong³, E J Kuijper³, F Fitzpatrick⁷

Affiliations

¹ Department of Medical Microbiology, Leiden University Medical Centre, Leiden, the Netherlands. Electronic address: [email protected].
² Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland.
³ Department of Medical Microbiology, Leiden University Medical Centre, Leiden, the Netherlands.
⁴ Department of Clinical Microbiology, Beaumont Hospital, Dublin, Ireland.
⁵ Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands.
⁶ Department of Geriatric and Stroke Medicine, Beaumont Hospital, Dublin, Ireland; Department of Geriatric and Stroke Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
⁷ Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Clinical Microbiology, Beaumont Hospital, Dublin, Ireland.

PMID: 31077778
DOI: 10.1016/j.jhin.2019.05.003

Abstract

A prevalence study in two nursing homes (one each in the Netherlands and Ireland) found four (11%) Dutch and six (9%) Irish residents colonized with 11 extended-spectrum beta-lactamase-producing Escherichia coli, 10 of which contained CTX-M-15. Four Dutch isolates, from three residents of the same ward, belonged to E. coli O25:H4, sequence type (ST) 131 and were part of the same cluster type by whole-genome sequencing. Four Irish residents on three different wards were colonized with an identical E. coli O89:H9, ST131, complex type 1478. Cross-transmission between three Irish wards may reflect differences in nursing home infrastructure, specifically communal areas and multi-bedded resident rooms.

Keywords: Clostridium difficile; Colonization; Extended-spectrum beta-lactamase-producing Enterobacteriaceae; Long term care facility; Multi-drug-resistant organisms; Nursing homes.

MeSH terms

Aged
Aged, 80 and over
Disease Transmission, Infectious*
Escherichia coli / enzymology*
Escherichia coli / genetics
Escherichia coli / isolation & purification
Escherichia coli Infections / epidemiology*
Escherichia coli Infections / transmission
Female
Genotype
Humans
Ireland / epidemiology
Male
Molecular Epidemiology
Molecular Typing
Netherlands / epidemiology
Nursing Homes*
Prevalence
beta-Lactamases / genetics
beta-Lactamases / metabolism*

Substances

beta-Lactamases