Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

Kunal K Jakharia; Ghassan Ilaiwy; Siobhan S Moose; Masashi Waga; Lakshmi Appalla; Joel D McAlduff; Lynne V Karanfil; Patrick T McGann; Glenn W Wortmann

doi:10.1017/ice.2019.124

Use of whole-genome sequencing to guide a Clostridioides difficile diagnostic stewardship program

Infect Control Hosp Epidemiol. 2019 Jul;40(7):804-806. doi: 10.1017/ice.2019.124. Epub 2019 May 15.

Authors

Kunal K Jakharia¹, Ghassan Ilaiwy¹, Siobhan S Moose², Masashi Waga³, Lakshmi Appalla⁴, Joel D McAlduff⁵, Lynne V Karanfil⁶, Patrick T McGann⁴, Glenn W Wortmann²

Affiliations

¹ Department of Internal Medicine,MedStar Washington Hospital Center,Washington,DC.
² Departments of Infection Prevention and Infectious Diseases,MedStar Washington Hospital Center,Washington,DC.
³ Department of Pathology and Laboratory Medicine,MedStar Washington Hospital Center,Washington,DC.
⁴ Multi-Drug Resistant Organism Repository and Surveillance Network (MRSN),Walter Reed Army Institute of Research,Silver Spring,MD.
⁵ Information Services,MedStar Health,Columbia,Maryland.
⁶ Infection Prevention,MedStar Institute for Quality and Safety,Columbia,Maryland.

PMID: 31088580
DOI: 10.1017/ice.2019.124

Abstract

Whole-genome sequencing (WGS) has yielded new insights into the transmission patterns of healthcare facility-onset Clostridioides difficile infection (HO-CDI). WGS results prompted a focused diagnostic stewardship program, which was associated with a significant and sustained decrease in HO-CDI at large, urban hospital.

MeSH terms

Clostridioides difficile / genetics*
Clostridioides difficile / isolation & purification*
Clostridium Infections / diagnosis*
Clostridium Infections / transmission*
Cross Infection / diagnosis*
Cross Infection / microbiology
Cross Infection / transmission
Genome, Bacterial
Health Facilities
Humans
Ribotyping
Whole Genome Sequencing