High serum levels of soluble interleukin-2 receptors in sarcoidosis

Sarcoidosis. 1987 Mar;4(1):25-7.

Abstract

We provide evidence that high levels of soluble interleukin-2 receptor (sIL-2R) are present in the serum of patients with sarcoidosis. Because sIL-2R is capable of binding to its ligand (IL-2), the increased serum levels of this molecule could induce a starvation of IL-2. This mechanism could help to explain a number of immunological abnormalities extensively reported in these patients and generally attributed to not yet identified serum inhibitory factors.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Interleukin-2 / analysis*
  • Lung Diseases / blood*
  • Male
  • Receptors, Immunologic / analysis
  • Receptors, Interleukin-2
  • Sarcoidosis / blood*
  • Solubility

Substances

  • Interleukin-2
  • Receptors, Immunologic
  • Receptors, Interleukin-2