Low-grade Serous Neoplasia of the Female Genital Tract

Ann K Folkins; Teri A Longacre

doi:10.1016/j.path.2019.02.006

Low-grade Serous Neoplasia of the Female Genital Tract

Surg Pathol Clin. 2019 Jun;12(2):481-513. doi: 10.1016/j.path.2019.02.006.

Authors

Ann K Folkins¹, Teri A Longacre²

Affiliations

¹ Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address: [email protected].
² Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.

PMID: 31097112
DOI: 10.1016/j.path.2019.02.006

Abstract

Low-grade serous neoplasia of the gynecologic tract includes benign (serous cystadenomas), borderline, and malignant lesions (low-grade serous carcinoma). Classification of these lesions relies on rigorous attention to several pathologic features that determine the prognosis and the need for adjuvant therapy. Risk stratification of serous borderline tumor behavior based on histologic findings and criteria for low-grade serous carcinoma are the primary focus of this article, including the redesignation of invasive implants of serous borderline tumor as low-grade serous carcinoma based on the similar survival rates. The molecular underpinnings of these tumors are also discussed, including their potential for prognostication.

Keywords: Low-grade serous carcinoma; Serous borderline tumor; Serous carcinoma.

Publication types

Review

MeSH terms

Carcinoma in Situ / diagnosis
Carcinoma in Situ / pathology
Cystadenocarcinoma, Serous / diagnosis
Cystadenocarcinoma, Serous / pathology*
Cystadenoma, Serous / diagnosis
Cystadenoma, Serous / pathology*
Diagnosis, Differential
Female
Humans
Neoplasm Grading
Neoplasm Invasiveness
Ovarian Neoplasms / diagnosis
Ovarian Neoplasms / pathology*