Transcriptional responses to DNA damage

Erica Silva; Trey Ideker

doi:10.1016/j.dnarep.2019.05.002

Transcriptional responses to DNA damage

DNA Repair (Amst). 2019 Jul:79:40-49. doi: 10.1016/j.dnarep.2019.05.002. Epub 2019 May 7.

Authors

Erica Silva¹, Trey Ideker²

Affiliations

¹ Department of Medicine, University of California San Diego, La Jolla, California, USA; Biomedical Sciences Program, University of California San Diego, La Jolla, California, USA. Electronic address: [email protected].
² Department of Medicine, University of California San Diego, La Jolla, California, USA; Biomedical Sciences Program, University of California San Diego, La Jolla, California, USA; Program in Bioinformatics, University of California San Diego, La Jolla, California, USA; Department of Bioengineering, University of California San Diego, La Jolla, California, USA. Electronic address: [email protected].

Abstract

In response to the threat of DNA damage, cells exhibit a dramatic and multi-factorial response spanning from transcriptional changes to protein modifications, collectively known as the DNA damage response (DDR). Here, we review the literature surrounding the transcriptional response to DNA damage. We review differences in observed transcriptional responses as a function of cell cycle stage and emphasize the importance of experimental design in these transcriptional response studies. We additionally consider topics including structural challenges in the transcriptional response to DNA damage as well as the connection between transcription and protein abundance.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Cell Cycle
DNA Damage*
Humans
Stress, Physiological / genetics
Transcription, Genetic*
Yeasts / genetics

Abstract

Publication types

MeSH terms

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