Gold induced thrombocytopenia: 12 cases and a review of the literature

Semin Arthritis Rheum. 1987 May;16(4):287-93. doi: 10.1016/0049-0172(87)90006-0.

Abstract

Gold induced thrombocytopenia is immune mediated, with the production of platelet associated IgG leading to peripheral platelet destruction. An association with HLA-DR3 has been demonstrated. Corticosteroid therapy is effective in treatment, although other modes of therapy may be as efficacious.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / immunology
  • Blood Platelets / immunology
  • Gold / adverse effects*
  • Gold / therapeutic use
  • Gold Sodium Thiomalate / adverse effects
  • Gold Sodium Thiomalate / therapeutic use
  • HLA-DR Antigens / analysis
  • HLA-DR3 Antigen
  • Humans
  • Immunoglobulin G / analysis
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / immunology

Substances

  • HLA-DR Antigens
  • HLA-DR3 Antigen
  • Immunoglobulin G
  • Gold Sodium Thiomalate
  • Gold