Synapsins regulate α-synuclein functions

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11116-11118. doi: 10.1073/pnas.1903054116. Epub 2019 May 20.

Abstract

The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin-a cytosolic protein with known roles in SV mobilization and clustering-is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.

Keywords: alpha synuclein; neurotransmission; synapsin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Mice
  • Neurons / metabolism
  • Synapses / metabolism
  • Synapsins / metabolism*
  • Synaptic Vesicles / metabolism*
  • alpha-Synuclein / metabolism*

Substances

  • Synapsins
  • alpha-Synuclein