Abstract
Acute kidney injury (AKI) is a frequent and serious complication of orthotopic liver transplantation (OLT), with a significant impact on mortality, graft survival, and chronic kidney disease. Currently, the diagnosis of AKI is based on changes in serum creatinine, which is a late marker, usually rising when there is already significant damage to the renal parenchyma. During the last 2 decades, various biomarkers have been studied in many clinical situations, mostly after cardiac surgery, in drug-induced AKI, or in sepsis. The present article summarizes the data on those biomarkers that have been evaluated for the prediction of AKI in patients undergoing OLT.
MeSH terms
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Acute Kidney Injury / blood
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Acute Kidney Injury / diagnosis*
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Acute Kidney Injury / etiology
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Acute Kidney Injury / urine
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Biomarkers / blood
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Biomarkers / urine
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Fatty Acid-Binding Proteins / blood
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Fatty Acid-Binding Proteins / metabolism*
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Fatty Acid-Binding Proteins / urine
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Hepatitis A Virus Cellular Receptor 1 / metabolism*
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Humans
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Interleukin-18 / blood
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Interleukin-18 / metabolism*
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Interleukin-18 / urine
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Lipocalin-2 / blood
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Lipocalin-2 / metabolism*
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Lipocalin-2 / urine
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Liver Transplantation / adverse effects*
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Postoperative Complications / blood
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Postoperative Complications / diagnosis*
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Postoperative Complications / etiology
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Postoperative Complications / urine
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Risk Factors
Substances
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Biomarkers
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FABP1 protein, human
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Fatty Acid-Binding Proteins
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HAVCR1 protein, human
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Hepatitis A Virus Cellular Receptor 1
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Interleukin-18
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Lipocalin-2