Integration of a photocleavable element into DNA nanoswitches

Chem Commun (Camb). 2019 Jun 11;55(46):6587-6590. doi: 10.1039/c9cc03069g. Epub 2019 May 22.

Abstract

Reconfigurable DNA nanostructures can be designed to respond to external stimuli such as nucleic acids, pH, small molecules and enzymes. In this study, we incorporated photocleavable linkers in DNA strands that trigger a conformational change in binary DNA nanoswitches. We demonstrate control of the output using UV light, with potential applications in biosensing and molecular computation.

MeSH terms

  • Base Sequence
  • Computers, Molecular*
  • DNA / chemistry
  • DNA / genetics*
  • Nanostructures / chemistry
  • Nanostructures / radiation effects*
  • Nucleic Acid Conformation
  • Nucleic Acid Hybridization
  • Organophosphorus Compounds / chemistry
  • Organophosphorus Compounds / radiation effects*
  • Ultraviolet Rays

Substances

  • Organophosphorus Compounds
  • DNA