Invasive Meningococcal Disease due to Nongroupable Neisseria meningitidis-Active Bacterial Core Surveillance Sites, 2011-2016

Open Forum Infect Dis. 2019 Apr 15;6(5):ofz190. doi: 10.1093/ofid/ofz190. eCollection 2019 May.

Abstract

We characterized 22 meningococcal disease cases due to nongroupable Neisseria meningitidis, a rare cause of invasive disease. Disease presentation and severity were similar to those for serogroupable meningococcal disease. However, 7 (32%) patients had complement deficiency or abnormal complement testing results, highlighting the importance of complement testing for nongroupable cases.

Keywords: Neisseria meningitidis; complement component deficiency; meningococcal disease; nongroupable.