Cabotegravir Is Not Associated With Weight Gain in Human Immunodeficiency Virus-uninfected Individuals in HPTN 077

Raphael J Landovitz; Sahar Z Zangeneh; Gordon Chau; Beatriz Grinsztejn; Joseph J Eron; Halima Dawood; Manya Magnus; Albert Y Liu; Ravindre Panchia; Mina C Hosseinipour; Ryan Kofron; David A Margolis; Alex Rinehart; Adeola Adeyeye; David Burns; Marybeth McCauley; Myron S Cohen; Judith S Currier

doi:10.1093/cid/ciz439

Cabotegravir Is Not Associated With Weight Gain in Human Immunodeficiency Virus-uninfected Individuals in HPTN 077

Clin Infect Dis. 2020 Jan 2;70(2):319-322. doi: 10.1093/cid/ciz439.

Authors

Raphael J Landovitz¹, Sahar Z Zangeneh², Gordon Chau², Beatriz Grinsztejn³, Joseph J Eron⁴, Halima Dawood⁵, Manya Magnus⁶, Albert Y Liu⁷, Ravindre Panchia⁸, Mina C Hosseinipour⁹, Ryan Kofron¹, David A Margolis¹⁰, Alex Rinehart¹⁰, Adeola Adeyeye¹¹, David Burns¹¹, Marybeth McCauley¹², Myron S Cohen⁴, Judith S Currier¹

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Center for AIDS Research and Education & Center for HIV Prevention, David Geffen School of Medicine at University of California, Los Angeles.
² Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
³ Laboratório de HIV, Instituto Nacional de Infectologia Evandro Chagas (INI), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.
⁴ Division of Infectious Diseases, University of North Carolina, Chapel Hill.
⁵ Department of Medicine, University of KwaZulu-Natal, Pietermaritzburg, Durban, South Africa.
⁶ Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, DC.
⁷ Bridge HIV, Population Health Division, San Francisco Department of Public Health, California.
⁸ Perinatal HIV Research Unit, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Soweto, South Africa.
⁹ Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine.
¹⁰ ViiV Healthcare, Research Triangle Park, Durham, North Carolina.
¹¹ Division of AIDS, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland.
¹² Science Facilitation Department, FHI 360, Washington DC.

Abstract

Studies in human immunodeficiency virus (HIV)-infected individuals suggest excess weight gain with integrase inhibitor-based antiretroviral therapy. The HIV Prevention Trials Network Study 077 evaluated changes in weight and fasting metabolic parameters in HIV-uninfected individuals randomized to cabotegravir or a placebo. No differences between arms were found for change in weight or fasting metabolic parameters overall or for subgroups.

Keywords: CAB; HIV uninfected; cabotegravir; weight gain.

Publication types

Randomized Controlled Trial
Research Support, N.I.H., Extramural

MeSH terms

Anti-HIV Agents / therapeutic use*
HIV
HIV Infections* / drug therapy
Humans
Pyridones*
Weight Gain*

Substances

Anti-HIV Agents
Pyridones
cabotegravir

Abstract

Publication types

MeSH terms

Substances

Grants and funding