Dissecting lung development and fibrosis at single-cell resolution

Donna L Farber; Peter A Sims

doi:10.1186/s13073-019-0645-7

Dissecting lung development and fibrosis at single-cell resolution

Genome Med. 2019 May 24;11(1):33. doi: 10.1186/s13073-019-0645-7.

Authors

Donna L Farber^{1

2

3}, Peter A Sims^{4

5}

Affiliations

¹ Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA. [email protected].
² Department of Surgery, Columbia University Irving Medical Center, New York, NY, 10032, USA. [email protected].
³ Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA. [email protected].
⁴ Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, 10032, USA. [email protected].
⁵ Department of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, NY, 10032, USA. [email protected].

Abstract

Single-cell transcriptome profiling has enabled high-resolution analysis of cellular populations in tissues during development, health, and disease. Recent studies make innovative use of single-cell RNA sequencing (scRNAseq) to investigate mechanisms that allow immune cells to interact with tissue components in the lung during development and fibrotic lung disease.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Cell Communication*
Cell Differentiation*
Fibrosis
Gene Expression Profiling / methods
Humans
Lung / cytology
Lung / growth & development
Lung / metabolism*
Lung / pathology
Single-Cell Analysis / methods*
Transcriptome*

Abstract

Publication types

MeSH terms

Grants and funding