USP30: protector of peroxisomes and mitochondria

Victoria Riccio; G Angus McQuibban; Peter Kijun Kim

doi:10.1080/23723556.2019.1600350

USP30: protector of peroxisomes and mitochondria

Mol Cell Oncol. 2019 Apr 16;6(3):1600350. doi: 10.1080/23723556.2019.1600350. eCollection 2019.

Authors

Victoria Riccio^{1

2}, G Angus McQuibban¹, Peter Kijun Kim^{1

2}

Affiliations

¹ Biochemistry Department, University of Toronto, Toronto, Canada.
² Cell Biology Department, Hospital for Sick Children, Toronto, Canada.

Abstract

In our recent publication, we describe a mechanism by which peroxisomes are protected from degradation by autophagy under basal conditions. Taking a page from mitophagy, peroxisomes also recruit the mitochondria deubiquitinating enzyme USP30 to counter the action of PEX2, the peroxisomal E3 ubiquitin ligase to regulate pexophagy.

Keywords: Mitophagy; pexophagy.