Abstract
A new dimeric quaternary protoberberine alkaloid, bispalmatrubine (1), and thirteen known compounds (2-14) were purified from the tubers of Tinospora dentata. Their structures were determined by spectroscopic and spectrometric analytical methods. Among the isolates, eight compounds were examined for their in vitro anti-inflammatory potential and several tested alkaloids displayed moderate inhibitory effects of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.
Keywords:
Menispermaceae; anti-inflammatory; elastase release; superoxide anion generation.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Berberine Alkaloids / chemistry
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Cytochalasin B / pharmacology
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Humans
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Molecular Structure
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N-Formylmethionine Leucyl-Phenylalanine / pharmacology
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Neutrophils / drug effects
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Neutrophils / metabolism
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Pancreatic Elastase / metabolism
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Plant Tubers / chemistry
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Plants, Medicinal / chemistry
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Superoxides / metabolism
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Tinospora / chemistry*
Substances
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Alkaloids
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Anti-Inflammatory Agents, Non-Steroidal
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Berberine Alkaloids
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Superoxides
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protoberberine
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Cytochalasin B
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N-Formylmethionine Leucyl-Phenylalanine
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Pancreatic Elastase