Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis

Qiaofen Fu; Nan Chen; Chunlei Ge; Ruilei Li; Zhen Li; Baozhen Zeng; Chunyan Li; Ying Wang; Yuanbo Xue; Xin Song; Heng Li; Gaofeng Li

doi:10.1080/2162402X.2019.1593806

Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis

Oncoimmunology. 2019 Apr 3;8(7):1593806. doi: 10.1080/2162402X.2019.1593806. eCollection 2019.

Authors

Qiaofen Fu^{1

2}, Nan Chen¹, Chunlei Ge², Ruilei Li², Zhen Li², Baozhen Zeng², Chunyan Li², Ying Wang², Yuanbo Xue², Xin Song², Heng Li¹, Gaofeng Li¹

Affiliations

¹ Department of Thoracic Surgery, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, People's Republic China.
² Department of Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, People's Republic China.

Abstract

Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma. This meta-analysis confirmed the favorable prognostic role of the CD3+, CD4+, CD8+, FOXP3+, and CD20+ TILs in the overall survival of melanoma patients and found an association between the TILs present and improved overall survival. Additionally, subgroup analysis demonstrated that brisk TILs were obviously associated with OS, RFS and DSS/MSS. Thus, TILs may be a predictive biomarker in melanoma. This analysis will provide more insight into the study of TILs and predictive biomarker.

Keywords: Melanoma; prognostic biomarkers; systematic review; tumor-infiltrating lymphocytes (TILs).

Publication types

Review
Research Support, Non-U.S. Gov't

Grants and funding

This study was supported by China Postdoctoral Science Foundation [No.2017M613008]; National Natural Science Foundation of China [No.81702295, No.81760554, No.81602029, No.81660389, No.81460356].