The Transcription Factor Deaf1 Modulates Engrailed-1 Expression to Regulate Skin Appendage Fate

J Invest Dermatol. 2019 Nov;139(11):2378-2381.e4. doi: 10.1016/j.jid.2019.05.007. Epub 2019 May 28.

Authors

Daniel Aldea¹, Blerina Kokalari¹, Christine Luckhart², Adam Aharoni¹, Paul R Albert², Yana G Kamberov³

Affiliations

¹ Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
² Brain and Mind Research Institute, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
³ Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: [email protected].

PMID: 31145909
DOI: 10.1016/j.jid.2019.05.007

No abstract available

Publication types

Letter
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cell Differentiation
Cell Line
Chromatin Immunoprecipitation
Conserved Sequence / genetics
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Gene Expression Regulation
Hair Follicle / physiology*
Homeodomain Proteins / genetics
Homeodomain Proteins / metabolism*
Humans
Mice
Mice, Knockout
RNA, Small Interfering / genetics
Skin / pathology*
Sweat Glands / physiology*
Transcription Factors / genetics
Transcription Factors / metabolism*

Substances

DEAF1 protein, human
DNA-Binding Proteins
Deaf1 protein, mouse
EN1 protein, human
En1 protein, mouse
Homeodomain Proteins
RNA, Small Interfering
Transcription Factors