Novel Approaches in Ovarian Cancer Research against Heterogeneity, Late Diagnosis, Drug Resistance, and Transcoelomic Metastases

Int J Mol Sci. 2019 May 29;20(11):2649. doi: 10.3390/ijms20112649.

Abstract

The development of modern technologies has revolutionised science and has had a huge impact on biomedical studies. This review focuses on possible tools that scientists can use to face the challenges of fighting ovarian cancer. Ovarian cancer is the deadliest gynaecologic malignancy and, even after years of study, the mortality has not decreased significantly. In the era of sequencing and personalised and precision medicine, we are now closer than ever to helping patients and physicians in regard to treatment and diagnosis of this disease. This work summarises the newest findings in the development of ovarian cancer research.

Keywords: cancer stem cells; epigenomics; genomics; high-grade serous ovarian cancer; metastases; omics; ovarian cancer; transcriptomics.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Drug Resistance, Neoplasm / genetics*
  • Early Detection of Cancer / methods*
  • Female
  • Genomics / methods*
  • Humans
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology

Substances

  • Biomarkers, Tumor