Beneficial Noncancerous Mutations in Liver Disease

Miryam Müller; Stuart J Forbes; Thomas G Bird

doi:10.1016/j.tig.2019.05.002

Beneficial Noncancerous Mutations in Liver Disease

Trends Genet. 2019 Jul;35(7):475-477. doi: 10.1016/j.tig.2019.05.002. Epub 2019 May 28.

Authors

Miryam Müller¹, Stuart J Forbes², Thomas G Bird³

Affiliations

¹ Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK.
² MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH164TJ, UK; MRC Centre for Regenerative Medicine, University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. Electronic address: [email protected].
³ Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH164TJ, UK.

PMID: 31151757
DOI: 10.1016/j.tig.2019.05.002

Abstract

Chronic liver disease results in fibrosis and cancer. While injury is associated with mutational burden, a recent study (Zhu et al. Cell 2019;177:608-621) highlights that not all positively selected mutations in the liver are precancerous. Indeed, some may be beneficial to the ability of the liver to not only withstand injury , but also to regenerate.

Publication types

Comment

MeSH terms

Carcinoma, Hepatocellular*
Humans
Liver
Liver Neoplasms*
Mutation
Regeneration

Grants and funding

26813/CRUK_/Cancer Research UK/United Kingdom