WDSPdb: an updated resource for WD40 proteins

Jing Ma; Ke An; Jing-Bo Zhou; Nuo-Si Wu; Yang Wang; Zhi-Qiang Ye; Yun-Dong Wu

doi:10.1093/bioinformatics/btz460

WDSPdb: an updated resource for WD40 proteins

Bioinformatics. 2019 Nov 1;35(22):4824-4826. doi: 10.1093/bioinformatics/btz460.

Authors

Jing Ma¹, Ke An¹, Jing-Bo Zhou¹, Nuo-Si Wu², Yang Wang^{3

4}, Zhi-Qiang Ye¹, Yun-Dong Wu^{1

5}

Affiliations

¹ Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
² College of Information Engineering, Shenzhen University, Shenzhen 518060, China.
³ Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
⁴ Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
⁵ College of Chemistry, Peking University, Beijing 100871, China.

Abstract

Summary: The WD40-repeat proteins are a large family of scaffold molecules that assemble complexes in various cellular processes. Obtaining their structures is the key to understanding their interaction details. We present WDSPdb 2.0, a significantly updated resource providing accurately predicted secondary and tertiary structures and featured sites annotations. Based on an optimized pipeline, WDSPdb 2.0 contains about 600 thousand entries, an increase of 10-fold, and integrates more than 37 000 variants from sources of ClinVar, Cosmic, 1000 Genomes, ExAC, IntOGen, cBioPortal and IntAct. In addition, the web site is largely improved for visualization, exploring and data downloading.

Availability and implementation: http://www.wdspdb.com/wdsp/ or http://wu.scbb.pkusz.edu.cn/wdsp/.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Genome*
Proteins
Software*

Substances

Proteins