A Viral Protein Mimics Histone to Hijack Host MORC3

Liang Zhu; Jun Qin

doi:10.1016/j.str.2019.05.007

A Viral Protein Mimics Histone to Hijack Host MORC3

Structure. 2019 Jun 4;27(6):883-885. doi: 10.1016/j.str.2019.05.007.

Authors

Liang Zhu¹, Jun Qin²

Affiliations

¹ Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA.
² Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA. Electronic address: [email protected].

PMID: 31167123
DOI: 10.1016/j.str.2019.05.007

Abstract

Microrchidia 3 (MORC3) is an ATPase and a regulator of influenza A virus (IAVs). In this issue of Structure, Zhang et al. (2019b) solved the crystal structure of human MORC3 in complex with the IAV protein NS1, providing a mechanism for targeting MORC3 by IAVs to regulate viral infection.

Publication types

Comment

MeSH terms

Adenosine Triphosphatases
DNA-Binding Proteins
Histones
Humans
Influenza A virus*
Influenza, Human*
Viral Proteins

Substances

DNA-Binding Proteins
Histones
Viral Proteins
Adenosine Triphosphatases
MORC3 protein, human

Abstract

Publication types

MeSH terms

Substances

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