Abstract
Anaerobic bacteria represent an underexplored source of bioactive natural products with unusual structural features. Here we report the isolation and structure elucidation of an antimycobacterial natural product, clostroindolin, produced by Clostridium beijerinckii. Furthermore, we provide first insights into structure activity relationships, which might guide the development of novel antibiotics against mycobacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Cell Line, Tumor
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Clostridium beijerinckii / chemistry*
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Human Umbilical Vein Endothelial Cells
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Humans
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Indole Alkaloids / chemical synthesis
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Indole Alkaloids / chemistry
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Indole Alkaloids / pharmacology*
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Molecular Structure
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Mycobacteriaceae / drug effects
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Pyrones / chemical synthesis
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Pyrones / chemistry
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Pyrones / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Indole Alkaloids
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Pyrones