Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on Ethylzingerone - 'Hydroxyethoxyphenyl Butanone' (HEPB) - Cosmetics Europe No P98 - CAS No 569646-79-3 - Submission II (eye irritation)

SCCS members; External experts

doi:10.1016/j.yrtph.2019.05.018

Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on Ethylzingerone - 'Hydroxyethoxyphenyl Butanone' (HEPB) - Cosmetics Europe No P98 - CAS No 569646-79-3 - Submission II (eye irritation)

Regul Toxicol Pharmacol. 2019 Oct:107:104393. doi: 10.1016/j.yrtph.2019.05.018. Epub 2019 Jun 4.

Authors

SCCS members; External experts

Collaborators

Ulrike Bernauer¹, Laurent Bodin², Qasim Chaudhry³, Pieter Coenraads⁴, Maria Dusinska⁵, Janine Ezendam⁶, Eric Gaffet⁷, Corrado Lodovico Galli⁸, Berit Brunstad Granum⁹, Eirini Panteri¹⁰, Vera Rogiers¹¹, Christophe Rousselle¹², Maciej Stępnik¹³, Tamara Vanhaecke¹¹, Susan Wijnhoven¹⁴, Aglaia Koutsodimou¹⁵, Alain Simonnard¹⁶, Wolfgang Uter¹⁷

Affiliations

¹ Federal Institute for Risk Assessment (BfR), Berlin, Germany.
² Alternative Energies and Atomic Energy Commission (CEA), Saclay, France.
³ Institute of Food Science & Innovation, University of Chester, United Kingdom.
⁴ University Medical Center Groningen, Groningen, The Netherlands.
⁵ Norwegian Institute for Air Research (NILU), Kjeller, Norway.
⁶ National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
⁷ Institute Jean Lamour (UMR 7198 CNRS - Université de Lorraine), Nancy, France.
⁸ Faculty of Pharmaceutical Sciences University of Milan, Italy.
⁹ Norwegian Institute of Public Health, Oslo, Norway.
¹⁰ National and Kapodistrian University of Athens, School of Pharmacy, Division of Pharmaceutical Chemistry, Athens, Greece.
¹¹ Vrije Universiteit, Brussels, Belgium.
¹² French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Maisons-Alfort, France.
¹³ Nofer Institute of Occupational Medicine, Łódź, Poland.
¹⁴ RIVM, Centre for Safety of Substances and Products (VSP), Centre for Substances and Integrated Risk Assessment (SIR), Bilthoven, The Netherlands.
¹⁵ General Chemical State Laboratory, Greece.
¹⁶ European Registered Toxicologist (ERT), retired from National Institute for Research and Safety (INRS).
¹⁷ University of Erlangen/Nürnberg, Germany.

PMID: 31170420
DOI: 10.1016/j.yrtph.2019.05.018

Abstract

Based on the new information provided by the Applicant, the SCCS considers the use of Hydroxyethoxyphenyl Butanone (HEPB) as a cosmetic preservative in rinse-off, oral care and leave-on cosmetic products with a maximum concentration of 0.7% safe with regard to eye irritation.

Keywords: CAS 569646-79-3; Cosmetics Europe No P98; Ethylzingerone; Regulation 1223/2009; SCCS; SCCS/1604/18; Scientific opinion; ‘Hydroxyethoxyphenyl Butanone’ (HEPB).

MeSH terms

Butanones / toxicity*
Consumer Product Safety
Cosmetics / toxicity*
Eye / drug effects*
Humans
Preservatives, Pharmaceutical / toxicity*

Substances

Butanones
Cosmetics
Preservatives, Pharmaceutical