Simultaneous comparison between strain and shear wave elastography of breast masses for the differentiation of benign and malignant lesions by qualitative and quantitative assessments

Purpose: To compare the addition of diagnostic strain elastography (SE) and shear wave elastography (SWE) values to the conventional B-mode ultrasonography in differentiating between benign and malignant breast masses by qualitative and quantitative assessments.

Materials and methods: B-mode ultrasound, SE, and SWE were simultaneously performed using one ultrasound system in 148 breast masses; 88 of them were malignant. The breast imaging reporting and data system category in the B-mode, Tsukuba score (SE_Tsu), Fat-Lesion-Ratio (SE_FLR) in SE, and five-point color assessment (SWE_col) and elasticity values (SWE_ela) in SWE were assessed. The results were compared using the area under the receiver-operating characteristic curve (AUC).

Result: The AUC for B-mode and each elastography were similar (B-mode, 0.889; SE_Tsu, 0.885; SE_FLR, 0.875; SWE_col, 0.881; SWE_ela, 0.885; P > 0.05). The combined sets between B-mode and either of the elastography technique showed good diagnostic performance (B-mode + SE_Tsu, 0.903; B-mode + SE_FLR, 0.909; B-mode + SWE_col, 0.919; B-mode + SWE_ela, 0.914). B-mode + SWE_col and B-mode + SWE_ela showed a higher AUC than B-mode alone (P = 0.026 and 0.029), and B-mode + SE_Tsu and B-mode + SE_FLR showed comparable AUC to B-mode alone (P = 0.196 and 0.085). There was no significant difference between qualitative and quantitative assessments for the combined sets of B-mode and elastography (P > 0.05).

Conclusion: The addition of both SE and SWE to B-mode ultrasound improved the diagnostic performance with increased AUC, and especially SWE was more useful than SE, and no significant difference was found between qualitative and quantitative assessments.