Synthesis and antiviral activity of some imidazo[1,2-b][1,3,4]thiadiazole carbohydrate derivatives

Carbohydr Res. 2019 Jul 1:480:61-66. doi: 10.1016/j.carres.2019.05.003. Epub 2019 May 21.

Abstract

Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junín virus (the etiological agent of Argentine hemorrhagic fever). The p-chlorophenyl derivatives showed antiviral activity in a range of micromolar concentration.

Keywords: Antiviral activity; D-Ribo derivatives; D-Xilo derivatives; Imidazo[2,1-b][1,3,4]thiadiazole; Junín virus.

MeSH terms

  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Chemistry Techniques, Synthetic
  • Junin virus / drug effects
  • Ribose / chemistry*
  • Thiadiazoles / chemical synthesis*
  • Thiadiazoles / chemistry
  • Thiadiazoles / pharmacology*
  • Xylose / chemistry*

Substances

  • Antiviral Agents
  • Thiadiazoles
  • Ribose
  • Xylose