Protective Properties of Lanthanum Nitrate against Pathogens with Various Morphological and Functional Properties

A S Vedenkin; D N Vtyurina; E A Grigorieva; A A Litvin; M G Mikhaleva; T N Nikolaeva; A V Pronin; S V Stovbun

doi:10.1007/s10517-019-04458-4

Protective Properties of Lanthanum Nitrate against Pathogens with Various Morphological and Functional Properties

Bull Exp Biol Med. 2019 May;167(1):50-52. doi: 10.1007/s10517-019-04458-4. Epub 2019 Jun 8.

Authors

A S Vedenkin¹, D N Vtyurina², E A Grigorieva³, A A Litvin¹, M G Mikhaleva¹, T N Nikolaeva³, A V Pronin³, S V Stovbun¹

Affiliations

¹ N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
² N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia. [email protected].
³ Laboratory of Natural Immunity, N. F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.

PMID: 31177449
DOI: 10.1007/s10517-019-04458-4

Abstract

Dose-dependent protective effects of lanthanum nitrate solution and gel were shown on the model of experimental infection caused by a virulent strain of Shigella flexneri 2a or opportunistic bacteria Klebsiella pneumoniae in outbred and DBA mice.

Keywords: Klebsiella pneumoniae; lanthanum nitrate; opportunistic bacteria; type I herpes simplex virus; virulent strain of Shigella flexneri 2a.

MeSH terms

Animals
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / pathogenicity
Lanthanum / pharmacology*
Mice
Mice, Inbred DBA
Shigella flexneri / drug effects
Shigella flexneri / pathogenicity
Simplexvirus / drug effects
Simplexvirus / pathogenicity

Substances

lanthanide nitrate
Lanthanum