Dyspnea and Wheezing as the Earliest Manifestations of Severe Fever with Thrombocytopenia Syndrome: The First Case Report

Intern Med. 2019 Sep 15;58(18):2731-2735. doi: 10.2169/internalmedicine.2660-19. Epub 2019 Jun 7.

Abstract

A 64-year-old Japanese woman developed fatigue, dyspnea, and wheezing in July. Although she had been undergoing treatment for chronic obstructive pulmonary disease for six days, she was transferred to our hospital with delirium and diarrhea. On admission, she had an eschar of 3 mm in diameter on her anterior chest. Polymerase chain reaction of her blood and eschar specimens led to the diagnosis of severe fever with thrombocytopenia syndrome. Chest computed tomography showed ground-glass opacities, suggesting noncardiogenic pulmonary edema or viral pneumonia. This is the first case report of severe fever with thrombocytopenia syndrome beginning with dyspnea and wheezing.

Keywords: dyspnea; noncardiogenic pulmonary edema; severe fever with thrombocytopenia syndrome; viral pneumonia; wheeze.

Publication types

  • Case Reports

MeSH terms

  • Bunyaviridae Infections / complications*
  • Bunyaviridae Infections / diagnosis
  • Diarrhea / etiology
  • Dyspnea / etiology*
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Middle Aged
  • Phlebovirus / genetics
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / diagnosis
  • Pulmonary Edema / diagnostic imaging
  • Pulmonary Edema / etiology*
  • Radiography, Thoracic
  • Respiratory Sounds / etiology*
  • Thrombocytopenia / etiology*
  • Tomography, X-Ray Computed